The Pillars of Spren Blood Testing

Spren's blood results are divided into four science-backed Pillars, each comprised of certified lab-standard blood markers. By monitoring these Pillars, you can make informed decisions and changes to your daily plan. Below are the four Pillars and why they matter:


Low-grade inflammation is a silent disruptor in the body, detrimental to healthy aging and peak performance. Research is increasingly pointing to a build-up of chronic inflammation (”inflammaging”) as a root cause for a range of health issues associated with getting older, including impaired cognition and increased risk of chronic disease. Spren’s inflammation score is based on homocysteine, ferrition, vitamin D and hs-CRP levels.

Metabolic Fitness

Metabolic fitness is a cornerstone, as it governs how your body efficiently uses energy from nutrition and internal stores. Good metabolic health is associated with optimal body composition, energy, memory, mood, skin health, fertility, longevity, and lower risk of chronic disease. Spren’s score is based on hemoglobin A1c, fasting insulin, triglyceride:HDL ratio and vitamin D levels.

Cardiovascular Health

A healthy heart and blood vessels are essential for healthy aging, peak performance and high quality of life. In addition to the run-of-the-mill lipid markers, Spren offers advanced lipid protein markers that shed more light on your risk for adverse cardiac events. The Cardiovascular Score is based on HDL, LDL, total cholesterol:HDL ratio, triglycerides, ApoA1, ApoB and ApoB:ApoA1 ratio.

Hormonal Balance

An overlooked aspect of healthy aging and peak performance is hormonal balance. Your body needs an optimal balance of important hormones and supportive micronutrients to manage mood, energy, muscle growth, fat distribution, sexual function, fertility, and mental function. Spren provides a sex-specific breakout for hormonal balance. The female score is derived from estradiol, folate, ferritin and homocysteine. The male score replaces estradiol with testosterone, testosterone:cortisol ratio and DHEA-S.


The reference ranges and insights presented in Spren are meant to improve readability and provide context, however you should consult with your physician for a more formal interpretation of your results. No communication from Spren is meant to be or should be taken as medical advice. Spren is a wellness-only service and is not designed to diagnose or treat any disease. If you are concerned about any of the data in Spren please consult your physician immediately.

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